L-Arginine- Does it Lower Blood Pressure? Pharmacist Recommendation

Does L-Arginine have the science to prove that it lowers blood pressure? Yes!

Should you take it? Find out in this video whether or not you need to add L-Arginine to your supplement cabinet.

In this video you'll learn:

  • What L-Arginine is

  • How does it lower blood pressure

  • How to get the same blood pressure lowering effects for free


  • L-arginine is an amino acid necessary for protein synthesis and proteins in muscle, bone, skin, hair, and virtually every other body part or tissue. It makes up the enzymes that power many chemical reactions.

  • L-arginine is a substrate for the nitric oxide synthase (NOS) enzyme. NOS in vascular endothelial cells converts L-arginine to nitric oxide (NO) which causes vasodilation and lower blood pressure.

  • No research to support a benefit in lowering cholesterol

  • No research to support a benefit in lowering blood sugar

  • Dietary Sources: It is found naturally in foods such as red meat, poultry, fish, and dairy products. Very rare to be deficient in this, no dietary recommendations.

  • Hypertension Supplement Dose: L-arginine 1 gram (1000 mg) twice daily.

  • Side Effects: L-arginine can cause abdominal pain and bloating, nausea, diarrhea, and gout. Can cause asthma exacerbations.

  • Drug Interactions: Use caution when you take other meds for high blood pressure especially ACE-Is and ARBs. Potassium-sparing diuretics can increase potassium levels. ED medications like Viagra and Cialis resulted in increased vasodilation.

Why would we look to a supplement for this mechanism of action to reduce blood pressure when we can achieve it naturally with exercise?

Benefits of exercise don’t just begin and end with Nitric Oxide production, every system in your body is improved when we exercise.

And there is so much data to support the benefits of exercise and blood pressure and just overall health.

If you have no energy to exercise or just don’t feel like it… then it’s time to change your perspective.

You don’t need energy to exercise. You need exercise for energy.

I believe we have to generate that energy, you’re not just all of a sudden going to have energy, we have to make it. Think about a time when you were exercising regularly? How did you feel?

If you are anything like me, the story in my head at the thought of exercise is:

  • uncomfortable

  • it’s going to be hard

  • but it’s cold

  • but it’s hot

  • it’s going to take a lot of work

  • I don’t have time

Any of these sound familiar?

What we tell ourselves can literally change how we act, respond, and how successful we are at achieving what we are setting out to do. I had to reframe my thoughts.

I looked up mantras, motivational quotes, and videos on empowerment.

I didn’t come up with these on my own because I didn’t have that vocabulary playing in the head.

But after making a journal with all these quotes, I read them every morning.

And now, I can say that the story I tell myself about exercise is different.

It’s more like this:

People often say that motivation doesn’t last. Well, neither does bathing- that’s why we recommend it daily. -Zig Zigler

If you do what you’ve always done (sit at the table drinking coffee thinking about how you should be exercising), you’ll get what you’ve always gotten (no energy, drained, tired, dreading your next doctor’s appointment).

Stop wishing. Start doing.

I thought about giving up, but then I remembered who was watching.

Someone busier than you is working out right now.

Nothing will work unless you do. - John Wooden

What are your thoughts? Share them with me in the comments below? Do you take L-Arginine? Have you noticed a decrease in blood pressure from it? Do you exercise daily incorporating low intensity, high intensity, and strength training exercises?

Shareable quotes from this week’s episode.

exercise to lower blood pressure