Does the supplement Berberine help with blood pressure, diabetes, and cholesterol?

Have you ever heard of Berberine? Yeah, me either until I kept getting asked about it over in free community Facebook group.

When I first heard about Berberine, I honestly was like ‘oh no here’s another quick fix solution.’ But, after I reviewed a couple of studies showing proof that Berberine was effective to lower blood pressure, I decided to check it out further because I also saw the data for lowering blood sugar and cholesterol.

If you know me, then you know I have to give you the speech first about the power that you already have to lower your numbers before trying supplements and medications.

This power is so much more important than any pill you could ever take, and those are lifestyle changes.

Not only will they lower your numbers, but will help you generate energy, feel better, and feel confident so that you are in control of your health and out living your best adventure without your health or medications holding you back. Fill out this form to book a free consult if you are wondering what lifestyle changes could work for you or if you’ve already tried a lot of things and you’re not getting anywhere on your own.

You’ll hear a lot more of this in the video and whether or not Berberine is effective to lower blood pressure, fasting blood sugar, A1C, and cholesterol.. Click on the play button below to watch.

What you’ll learn:

  • In this video I review whether Berberine has the data to support the use to lower blood pressure, lower A1C, and lower cholesterol.

  • You have more power than you think. I go over the significance of lower numbers and how you can achieve the same through lifestyle changes to reduce or prevent medications.


  • Berberine is a bitter-tasting, yellow-colored, chemical that is found in the roots, rhizomes, and stem bark of various plants. Thanks to modern science, it’s extracted, purified, and delivered via a pill.

  • High Blood Pressure: reduces systolic blood pressure by 4.9 mmHg and diastolic blood pressure by 2 mmHg compared to treatment with amlodipine alone

  • Diabetes: Some clinical research shows that taking berberine 500 mg twice daily for 3 months can reduce glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), and post-prandial glucose (PPG) in subjects with type 2 diabetes.

    • The blood-glucose lowering effect of berberine has been attributed to its ability to increase insulin receptor expression (aka helps with insulin resistance)in patients with type 2 diabetes.

  • Cholesterol: reduces total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides

  • Dietary Sources: None

  • When to supplement: After maximization of all lifestyle changes to lower numbers and still need a small reduction in numbers to reach your goals or unable to tolerate other medications due to side effects. Make sure you speak with your doctor about starting any new supplements as your numbers and other medications need to be reviewed and watched. 

  • Supplement Recommendation: Berberine 500 mg three times a day. You can get this online from Amazon here or check with your local pharmacy or health food store.

  • Side Effects: Orally, berberine is generally well tolerated. Adverse effects reported in clinical trials include diarrhea, constipation, flatulence, vomiting, abdominal pain, and abdominal distention. Less commonly, berberine may cause rash or headache.

  • Drug Interactions:

    • Additive effects when used with blood pressure and blood sugar lowering drugs and increase the risk of hypotension and hypoglycemia (low blood pressure and low blood sugar).

    • Berberine can inhibit platelet aggregation. Use with caution with antiplatelet drugs include aspirin, cilostazol (Pletal), clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), and others.

    • Theoretically, taking berberine with drugs metabolized by CYP2C9 might increase drug levels and potentially increase the risk of adverse effects.

      • Some drugs metabolized by CYP2C9 include celecoxib (Celebrex), diclofenac (Voltaren), fluvastatin (Lescol), glipizide (Glucotrol), ibuprofen (Advil, Motrin), irbesartan (Avapro), losartan (Cozaar), phenytoin (Dilantin), piroxicam (Feldene), tamoxifen (Nolvadex), tolbutamide (Tolinase), torsemide (Demadex), and S-warfarin (Coumadin).

    • Theoretically, use of berberine with drugs metabolized by CYP2D6 might increase drug levels and potentially increase the risk of adverse effects.

      • Some drugs metabolized by CYP2D6 include amitriptyline (Elavil), codeine, desipramine (Norpramin), flecainide (Tambocor), haloperidol (Haldol), imipramine (Tofranil), metoprolol (Lopressor, Toprol XL), ondansetron (Zofran), paroxetine (Paxil), risperidone (Risperdal), tramadol (Ultram), venlafaxine (Effexor), and others.

Want to know the proven system to lower your numbers? Click here to fill out a form and book a free consult to get your numbers back on track.

Shareable quotes from this week’s episode.

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What are your thoughts? Share them in the comments below.